Welcome to my journey
My research notes are free of copyright, and you may share
Website: www.susan-moore.co.uk
Facebook page: Susan Moore also Susan’s Cancer Journey
Email: susan.k.moore@btinternet.com
Mid November 2024 diagnosed with stage three high grade serous ovarian cancer. 6th Dec 2024 : CT Scan : Bilateral adnexal mass, solid cystic with peripheral nodules and internal septation.
Both lesions are extending to pelvic side wall.
Right measures 6.4 x 6 x 5. X 4 cm.
Left measures: 16 x 11 x 10 cm. (etc) As an artist and author, with a ‘curiosity’ about life and the universe, I wanted to know why I had cancer and more importantly, what I could do about it. I am not medically trained and was in the process of promoting a new book (available now from Amazon Books) ENCHANTED CASTLE with all profits going to children’s charity, BBC Children in Need. You can see more about this on my home page. The reason I began to research was the gloomy news there is no cure. My specialist informed me (gently) that first, she would arrange chemo to reduce the size of my tumour/s as they were too large to operate on. Next major operation 6 - 8 hours removing most of my 'inners'. Next, more chemo. And the cancer would return! Must confess, I was sceptical that I would survive as only 12% of women of my age live for more than 5 years after this treatment. I would also ‘age’ by about 10 years, so if I did survive, I would become a frail old lady. With this in mind, I was focussed on researching to try and find a better way.Fortunately, the NHS was very slow as we had Christmas and New Year in between my diagnosis, which gave me time to research before treatment. First chemo, Carboplatin 5th February 2025. (I refused platinum chemo with 2 more chemo’s). After first round I cancelled further chemo as too toxic. (My GP and Oncologist have refused to support me now. I pay privately for my own CA 125 blood tests to monitor my progression.) Cancer Stem Cells are not usually killed by chemotherapy. So, the cancer may return. My two aims are: ONE: to kill cancer cells to try and stop it progressing. TWO: to kill stem cells to try and stop it returning. CA125 BLOOD TEST RESULTSCA 125 diagnosis in November 2024 was 345.CA125 February 2025 pre carboplatin was 545.CA125 end February after carboplatin was 695CA125 end March was 645 (I began RSO protocol)
CA125 mid-April down to 230
CA 125 24th April down to 97CA 125 8th May up to 115 (Re-think and reintroduce fenben & cordyceps)Example of my diet: I started with great hope I could ‘starve’ my cancer by going Vegan with lots of juiced vegetables etc. It may have slowed its progress but didn’t cure it, so by February 2025, it was necessary to do more urgent research. (I am my own human guinea pig). Absolutely no sugars, no carbs i.e. no wheat bread, no cakes, no biscuits, no fruits (except blueberries). Drinks: filtered water, ginger & lemon tea with extra ginger, fruit tea with Hawthorne Berry powder, one cup organic coffee. Breakfast: I make gluten free seeded bread and have 1 slice toasted with lots of olive oil, nuts, almonds, walnuts and an organic avocado, some blueberries. Evening Meal: varies with different types of vegetables, including mushrooms, butter beans, broccoli, cauliflower, celery, raw garlic, black garlic. Sometimes a little meat, or fish, and lambs liver to prevent pernicious anaemia. Plus - Gut biome friendly foods, kefir water from Tibico, sauerkraut, inulin, etc. My ‘treat’ is a small piece of dark 85% chocolate occasionally after my evening meal.Email: susan.k.moore@btinternet.comMy research is mainly concerned with ovarian cancer although much of it applies to other cancers, but they are all different. I am not medically trained and my (simple) understanding of chemotherapy is that it ‘kills’ cancer cells and may save/extend your life. In the process, it also ‘kills’ good cells, affects your immune system and has many side effects. PLEASE DO YOUR OWN RESEARCH and double check everything I have written.There are some excellent You Tube interviews that explain how cancer is not often genetic. // Thomas N Seyfried The Cancer Expert on You Tube: The Diary of a CEO. 7 Oct 2024. // Mark Lintern interviews. The Fungal Link to Cancer. Also, Is the standard cancer theory wrong? // Book: by Jane McClelland, How to Starve cancer STARVING CANCER CELLS
Cancer cells need ‘sugar/glucose/fats’ to survive.
Imagine this triangle is a cancer cell(Adapted from Jane McLelland’s book, How to Starve Cancer)There are 3 sides, and you need to deprive ‘food’ from all angles to starve it.
Exercise immediately after eating helps to convert blood sugars from food into ‘energy’ and reduce feeding cancer cells. I ‘save’ my housework chores and do these after eating. i.e. dancing around the kitchen, or take my dog for a walk etc.
LIST OF SUPPLEMENTS BELOW - These are not a recommendation but a note of things I take. (Final pages are research notes of other anti-cancer things I haven’t tried.)
ANGELICA SINENSIS Dong Quai (organic powder- supplier Indigo Herbs). N-butylidene phthalide kills high grade serous ovarian stem cells by activating intrinsic apoptosis signalling pathways. Taking heaped teaspoon in hot water once or twice a day. Tastes ‘horrid’. Conflicting research on this. Some research says do not take for hormone driven cancers (i.e. breast & ovarian cancer.)
pmc.ncb.nim.nih.gov
Aspirin 75 mg coated. Inhibits cell proliferation and induce apoptosis in various cancer cell lines. Helps prevent metastasis. I take one tablet daily with food/evening meal. Most cancer patients do not die from initial tumour, but from metastasis i.e. the spread of cancer to other organs. Aspirin helps to prevent this. Blueberries – polyphenolic acids, and soy isoflavone genistein derivative, specific inhibition of ovarian Cancer Stem Cells. National Institute of Health (Library) Natural products that target Cancer Stem Cells.
Broccoli
eaten raw, cooked, and sprouted. (Sulforaphane, cancer-fighting plant
compound).
BERBERINE (METFORMIN
alternative) – 1 capsule before each meal. To lower blood glucose and
increase insulin sensitivity. (From British Supplements 422 mg Amur Cork tree
Extract.) (In vitro experiments, berberine reduces glycolysis and autophagy
levels, leading to the inhibition of ovarian cancer cell proliferation and
metastasis.) www.sciencedirect.com Berberine can take about 3 months to lower
blood sugar. Metformin works much faster in 4-5 days. Research shows combination of berberine, and
metformin can enhance the effects on blood sugar. Berberine can make it easier
to tolerate metformin with fewer metformin side effects. Berberine shown to
regulate both glucose metabolism and lipid metabolism. Berberine did not cause
changes in kidney or liver function tests. Powerful oral blood sugar-lower with
beneficial effects on fasting insulin and lipid metabolism. Berberine starting
dose (for diabetes)300 - 500 mg per day, increasing to 3 times a day.
Absorption in the gastrointestinal tract can be enhanced by taking milk
thistle. Metformin and berberine can cause flatulence, diarrhoea, constipation
and abdominal pain.
Bicarbonate of Soda (Baking soda). Cancer tumours are acidic. Bicarb is alkaline. An alkaline environment might be anti-cancer – but not enough research done. I take a small amount in my drinks or add extra to my baking. (Have ordered some bicarb capsules to make it easier to take.) Research exploring anti-cancer effects began in 1990s. Several in vivo experiments revealed potential anticancer effects. Sodium bicarbonate neutralises the acidity and increases the tumour PHe and might control tumour progression. If injected directly into the tumour, may kill the cancer cells.
Black Garlic (fermented and aged garlic) Has many bioactive compounds that give it medicinal properties, including ant- inflammatory and anti-cancer properties. Reduction of pro-inflammatory cytokines, ability to scavenge free oxygen radicals and induce apoptosis. Antiproliferative and antiangiogenic properties and inhibit the growth of cancer cells. (Not effective on some breast and lung cancer).Cordycepin (fungus) Induces apoptosis of human ovarian cancer cells. Taking 1 capsule per meal. (British Supplements. 488 mg Cordyceps extract, 195 mg Polysaccharides (can lower cholesterol). Adenosine 4.8 mgCordycepin (fungus) also known as 3-deoxyadenosine. Contains various bioactive ingredients, suggested to have anti-cancer potential. Adenosine derivatives from Cordyceps exert antitumour effects against ovarian cancer cells through ENT1-mediated transport, induction of AMPX signalling and consequent autophagic cell death. https://www.sciencedirect.comCORDYCEPS MILITARIS Results suggest that Cordyceps militaris induces apoptosis in ovarian cancer cells through TNF-a/TNFR1-mediated inhibition of NF-kB phosphorylation. IExhibits pharmacological activities, including antitumour properties through the regulation of the nuclear factor kappa B (NF-mB) signalling. Tumour Necrosis Factor (TNF) and TNF0a modulates cell survival and apoptosis through NF-kB signalling. However, the mechanism underlying its mode of action of the NF-kB pathway is unclear. Results suggest that Cordycepin Militaris inhibited ovarian cancer cell proliferation, survival, and migration, possibly through coordination between TNF-a/TNFR1 signalling and NF-kB activation. Taken together, our findings provide a new insight into a novel treatment strategy for ovarian cancer using Cordycepin Militaris. National Library of Medicinemed.ncbi.nim.nih.gov*Could interact with blood thinners and drugs that suppress the immune system. Also cause problems if you take medications to lower your blood sugar levels.
DOXYCYCLINE - Tetracycline Antibiotic. (Anti malaria treatment). Inhibits proliferation of epithelial ovarian cancer cells. Taking 1 capsule 100 mg mid-morning with lots of water, 3 days on 1 day off. Can make me sick!DOXYCYCLINE - (From Online Pharmacy). (to prevent malaria and treat infections caused by mites, ticks or lice. etc). Exhibits anti-inflammatory anti-tumour, and pro-apoptotic activity. Is being tested as chemotherapeutic agent for several cancers. Inhibits proliferation of epithelial ovarian cancer cells. (Used with cisplatin and doxycycline in different concentrations, cell viability was decreased in a dose dependent manner). https//pmc.ncbi.nim.gov. Avoid eating dairy, eggs, kale and spinach. It aims to slow down or kill bacteria by inhibiting its protein production and can induce a number of side effects such as diarrhoea, nausea, vomiting.Doxycycline, Azithromycin and Vit C (DAV) (National Library of Medicine pmc.ncbi.nim.nih.gov ). A potent combination therapy for targeting mitochondria and eradicating cancer stem cells. Trial conducted University of Pisa Hospital, aimed to assess the anti-proliferative and anti-CSC mechanistic actions of Doxycycline in early breast cancer patients. Promising results. Preliminary effects of Doxycycline on CSC propagation and employing a combination therapy with Azithromycin and Vit C. Azithromycin inhibits the large mitochondrial ribosome. Vit C acts as a mild pro-oxidant, which can produce free radicals, and as a consequence, induces mitochondrial biogenesis.Results indicate that a combination is more efficacious than the individual antibiotic in inhibiting CSCs propagation. Doxycyline inhibits the small mito-ribosome . Azithromycin blocks function of the large mito-ribosome as an off-target effect.(Note: combination may affect your gut biome.)
Fenbendazole I take this 4 days on, 3 days off. Animal worming and parasite medication for animals. (Kills worms by reducing their sugar/glucose uptake.) Mebendazole is the ‘human’ equivalent with a prescription. Taking 1 capsule per 10 kilos in weight. e.g. 5 x 50 mg capsules mixed with peanut butter and olive oil (No drinks with it as it is not water soluble).FENBENDAZOLE –mixed reviews on anti-cancer treatment for humans. (Many recommendations from people living with cancer). Mebendazole is the similar ‘human’ medication, but not available without a prescription. Research: Oral admin of FBZ inhibited tumour growth in a mouse model of xenograft ovarian cancer. FBZ has therapeutic potential for the treatment of ovarian cancer. bmccancer.biomedcentral.comExhibits several other mechanisms contributing to its ant-cancer effects, primarily by disrupting energy metabolism. https://ar.liarjournals.org Anticancer ResearchIvermectin (an anti-parasite drug) can suppress almost completely the growth of various human cancers, including ovarian cancer. Taking small amount most days (when I remember!)
IVERMECTIN - Anti-parasite drug can suppress ovarian cancer by regulating IncRNA-EIF5A3-mRNA axes. Its anticancer mechanism remains to be further studied at molecular levels. National library of Medicine. pmc.ncbi.nim.nih.gov
IVERMECTIN is believed to be safe and in much of the civilized world it is available over the counter, no prescription needed. However, in the UK it is not available and may be obtained from some (horse) suppliers if you have a horse or two! e.g. Hyperdrug.co.uk
Used as pesticides, insecticides and anti-parasitic. Inhibits glutamate-activate chloride channels. Inhibits pathways etc. Recommended Doses:· Low Dose 0.5 mg per kilo of body weight. Dr Tess Lawrie reported case of Stage 3 Ovarian Cancer, treated with chemo and 12 mg of IVM date. CA125 dropped 288 to 22 after 2 months. Tumour vanished.· Medium Dose: 1.0 mg per kilo body weight. Starting does for most cancers. No long-term side effects. · High Dose: 2.0 mg per kilo body weight. For very aggressive cancers. No long-term side effects. · Very High Dose: 2.5 mg per kilo body weight. For Extensive metastatic disease with poor prognosis. Possible short term and transient visual effects. Dr Shankara Chetty had a patient on this with no side effects.LORATADINE antihistamine - cationic amphiphilic (CAD) Induces cancer-specific cell death in experimental studies. (Good for lung cancer). Taking 1 capsule with evening meal most days. LORATADINE Reduction of around 20%-35% in ovarian cancer mortality. CADs a diverse group of compounds, accumulate in acidic lysosomes where they can induce permeabilization of the lysosomal membrane leading to cell death. The cancer cells, as opposed to normal cells, lysosomes are more abundant, larger and particularly susceptible to membrane permeabilization. CADS accumulate in acidic tumours, particularly in tumour lysosomes, therefore the dose range used in vitro experiments may be relevant for the concentrations achieved after oral antihistamine use. (Study done in Denmark) Antihistamines and Ovarian Cancer Survival: Nationwide Cohort Study and in Vitro Cell Viability Assay. pmc.ncbi.nim.nih.gov RSO (Rick Simpson cannabis oil). Highly recommended by cancer survivors. There are books on how it ‘cures’ cancer even late stage cancer. The first month I took a low dose, my CA125 went down to 230. // 2nd month high dose vaginal suppositories after two weeks down to 97. Four weeks, up to 115 – which may be because I had become relaxed about taking all my protocol? RSO (RICK SIMPSON CANNABIS OIL) There are many recommendations about RSO ‘curing’ a variety of cancers (and other illnesses). RSO is very expensive. To get the high THC you require you can find recipes on how to make it. i.e. The Medicinal Cannabis Oil Extraction by William Bentley. (a short easy to read book). // Marijuana Killed my Cancer by Erika M. Karohs, PH.D. (Step by step guide) // Rick Simpson Oil. Nature’s Answer for Cancer by Rick Simpson. UK Medical Clinics who supply medicinal cannabis with a doctor’s prescription advertise on Facebook include www.releaf.co.uk and CBI Medical.com, but there are about 30 Medical Clinics/ suppliers in the UK. Sour Sop – Graviola. Laboratory studies show can kill some types of cancer. I buy the pure fruit and pour it on top of blueberries. SOUR SOP – Graviola. (Expensive to buy). In laboratory studies, graviola extracts can kill some types of cancer cells, but there have not been any studies in humans. Many sites advertise and promote graviola as a cancer cure. Studies on animals found that graviola may lower blood sugar and blood pressure. 2015 systematic review found that several studies show positive results. But there still needs to be more clinical trials to test. // 2018 review found that graviola can be used as a chemo preventative agent.
QUERCETIN – (Available from Nature’s Best. 500 mg or British Supplements) has shown great anti-cancer and anti-inflammatory properties. I take 2 in the morning and 2 in the evening with meals.QUERCETIN – (flavonoid, found in many fruits, veg, seeds, red onions, kale etc. Sophora Japonica has shown great anti-cancer and anti-inflammatory properties. Despite obtaining good results, both in vitro and in vivo, few clinical studies have assessed the anti-cancer effects of quercetin particularly in ovarian cancer. Quercetin possess a cytotoxic impact on ovarian cancer cells. https://pmc.ncbi.nim.nih.govQuercetin has been shown to inhibit the proliferation of a wide range of cancers by causing apoptosis and /or cell cycle arrest. VITAMIN D3 - from Nature’s Best: 1000 iu (25 ug) x2 taking with meals (twice a day). (The sunshine vitamin).
Turmeric Curcumin. (20,000 mg from Nature’s Best or British Supplements). Anticancer potential by promoting cell apoptosis, suppressing cell cycle progression, inducing autophagy, inhibiting tumour metastasis. I am taking 2 in the morning and 2 in the evening with meals. TURMERIC CURCUMIN (20,000 mg from Nature’s Best.) Curcumin can delay ovarian cancer, increase its sensitivity to chemotherapy, and reduce chemotherapy drugs’ side effects. Anticancer potential by promoting cell apoptosis, suppressing cell cycle progression, inducing autophagy, inhibiting tumour metastasis, and regulating enzyme activity. // How curcumin affects autophagy in tumour cells is not very clear. In different types of malignant diseases, curcumin regulates autophagy differently. Liu et al, found that curcumin significantly induce LC3, ATG3 and Beclin1 expresion dose-dependent manner, and increase protective autophagy in OC cells. And further clarify that the underlying mechanism of this effect is through inhibiting the AAKT/mTOR/p7056K signalling pathway. After exposure to curcumin, the autophagic flux of OC cells increased in a dosage-dependent manner. Curcumin combined with the autophagy inhibitor chloroquine (CQ) or the knockdown of LC3B by siRNA significantly enhanced the sensitivity of cells toward curcumin treatment. These results revealed that autophagy induced by curcumin protects cancer cells from death. Simultaneously, Quetal found that curcumin’s new aminocarbonyl analog B19 can induce OC cells death of apoptosis and autophagy. Apoptosis significantly increased after combined treatment with the curcumin and autophagy inhibitor 3-MA. Therefore, the combination of autophagy inhibitors and curcumin is expected to solve the resistance of curcumin to OC.
Effects of CURCUMIN. Can inhibit tumour metastasis, includes cell invasion adhesion and angiogenesis. Shown that it inhibits metastasis in Ovarian Cancer cells by modulating several molecular targets Chemotherapy: (failure of treatment on OC). Curcumin overcomes Multi Drug Resistance through multiple mechanisms. Pre-treatment with curcumin not only decreased the expression and transcriptional activity of B-catenin, but also down regulated expression of BCl-XL etc. Recent studies found that curcumin’s anti-cancer properties are related to DNA methylation.Although curcumin shows abundant pharmacological activity, its instability, poor water solubility, and low bioavailability still limit its application in clinical treatment. The application of nanotechnology can increase bioavailability of curcumin by increasing the penetration of small intestine, avoiding the degradation of the intestinal condition, etc.
Curcumin has the ability to weaken the adhesion and invasion of EOC speres to the extracellular matrix and mesothelial monolayer, thereby inhibiting metastasis. A curcumin analogue GO-Y030 depletes cancer stem cells by inhibiting the interaction between HSP70/HSP50 complex and its substrates. https://pmc.ncbi.nim.nih.gov
CURCUMIN is thought to have antioxidant properties which means it may decrease swelling and inflammation. It’s being explored as a cancer treatment in part because inflammation appears to play a role in cancer. Laboratory and animal research suggests that curcumin may prevent cancer, slow the spread of cancer, make chemotherapy more effective and protect healthy cells from damage by radiation therapy. Mayo Clinic. - - - - - - - - - - -
FURTHER RESEARCH NOTES – I AM NOT CURRENTLY USING THESE BUT have made notes for future reference
APRICOT KERNELS recommended by some cancer patients. They contain 2 molecules of glucose, 1 cyanide, 1 benzaldehyde. The glucose is taken by cancer cells, and they also take in the poisons! (I haven’t done any research on this, but taking more then 3 a day is not recommended).
Artemisinin – potent antimalarial drug derived from the sweet wormwood plant. Artemisia annua. Foundation for the most effective malaria treatments. Anti-cancer research: Reduces cell proliferation and induces apoptosis in neuroblastoma. Inhibit cell growth in human ovarian cancer. Might affect blood sugar levels.
INTERMITTENT FASTING is something some cancer patients do on a regular basis to starve their cancer cells. I haven’t researched. I did try a 24 hour fast and was okay. Others do it for 3+ days. IMMUNO CANCER THERAPYDendritic Cell Therapy. Available at some clinics. May cost approx. £30,000 for a package that includes diet etc. // Take blood from you, and then intravenously give back your blood with cells that recognise cancer cells and destroy them. // This treatment is only about 5% - !5% effective for ovarian cancer. // CIMETIDINE Brand name Tagamet. Histamine H2 receptor, treats heartburn and peptic ulcers. Small trial, 28 advanced serous ovarian cancer patients, chemo augmented with CIM at a dose of 800mg/day, 2 weeks before surgery and continuing with chemo showed significant improvements in overall survival. Inhibits cancer cell adhesion to endothelial cells and prevents metastasis by blocking E-selectin expression.
CHLOROQUINE (used to treat malaria). Expected to have diverse effects on cancer progression. Inhibition of late autophagy can affect cell survival, as well as antigen processing and presentation in the immune system. The chloroquine family of drugs have been used for the prevention and treatment of malaria. Autophagy is an intrinsic cellular mechanism by which cells degrade and recycle their dysfunctional components through lysosomes. Contrasting roles of autophagy has been reported in cancer cells. It may function as a tumour suppressor mechanism in cells by degrading damaged proteins and organelles and therefore preventing their accumulation in the cells. However, it can also promote cell survival by recycling intracellular organelles and proteins in tumours. Hence autophagy is considered a mechanism potential leading to invasion, chemotaxis, trans-differentiation and clonogenicity of tumour cells.
HIGH DOSE VITAMIN C intravenously IVC, (not orally). It turns from an antioxidant into a pro-oxidant giving off free oxygen to the area around a tumour. The reaction oxygen species (ROS) is hydrogen peroxide (H202). This oxygen production near the cell causes a kind of ‘rusting ’ and allows the cell to be attacked and killed. ‘Mounting evidence indicates that Vit C has potential to be a potent anti-cancer agent when administered intravenously in high doses. Early clinical trials have confirmed safety and indicated efficacy in eradicating tumour cells of various cancer types. .. Moreover high dose IVC is powerful as an adjuvant treatment for cancer, acting synergistically with many standard (chemo) therapies, as well as a method for mitigating the toxic side-effects of chemotherapy.– Journal of Experimental & Clinical Cancer Research.(There are pages of information on Intravenous Vit. C. IVC – both positive and negative). Based on the observations that the combination of parenteral ascorbate with carboplatin and paclitaxel, synergistically inhibited ovarian cancer in preclinical ovarian cancer models. Ma et al conducted clinical trial assessing effectiveness and toxicity of such treatment with stage III and IV ovarian cancer. The median time for disease progression was 8.75 months longer with IVC. // Ascorbic acid added to paclitaxel/carboplatin therapy in stage II and IV ovarian cancer patients reduced chemotherapy induced toxicity. IVC did not increase the rate of graded 3 or 4 toxicities. Also not observed grade 5 treatment -related toxicities (death). Also, authors proved that grade 1 and grade 2 toxicities i.e. neurotoxicity, bone marrow, infections, hepatobiliary/pancreatic toxicity, dermatological toxicity, and toxicities in the skin, renal genitourinary, pulmonary and gastrointestinal systems, were significantly decreased in the group received ascorbic acid, when compared to sole chemotherapy. Possible side effects during IVC administration, alleviated same day as infusion: Mild light- headedness and nausea. Thirst, dry mouth and skin, increased urinary flow, diarrhoea, headache. pmc.ncbi.nim.nih.gov.
MISTLETOE Therapy1)Randomized and non-randomized studies Mistletoe extracts in addition to basic oncological treatments, had a positive effect on survival time with patients with ovarian cancer and solid cancers. The efficacy is still controversial. Injectable, not available commercially in the USA and not approved as a treatment for people with cancer. Is available as capsule/powder form in the UK.
(Was recommended as a treatment for me by a doctor from the Wellness Clinic to do intravenously. I didn't accept treatment.)
Trial: Randomised studies: Mistletoe extracts Iscador might prolong overall survival of ovarian cancer patients. Pubmed.ncbi.nim.nih.gov2) Systematic review: Mistletoe - Quality of Life and toxicity Sept & Oct 2017. Search identified 3647 articles and 28 publications. 2639 patients included in review. In nearly all studies, mistletoe was added to conventional therapy. Regarding quality of life, 17 publications reported results. Studies with better methodological quality show less or no effects on quality of life.Conclusions: Quality of Life or reduction of treatment – associated side effects, a thorough review of the literature does not provide any indication to prescribe mistletoe to patients with cancer.METHYLENE BLUE METABOLIC THERAPYRestrains in Vivo Ovarian Tumour GrowthStudy confirms the potential of methylene blue (MB) in a treatment strategy for ovarian cancer. Findings revealed MBs ability to impede ovarian cancer progression, especially against tumours showing resistance to conventional chemotherapies (carboplatin).
NICOLSAMIDE oral anthelminthic. (overcomes cisplatin resistance in human ovarian cancer). To treat tapeworms, anti-cancer. Effectively inhibits cell proliferation, supresses cell migration and induces cell apoptosis in cisplatin-resistant ovarian cancer cells at a very low micromole range. Further demonstrated NA effectively inhibited xenograft tumour growth of the SKOV3CR cells.
WEIGHT LOSS INJECTIONS (new news!) could help prevent cancer and have anti-cancer effect. (My Question – is this because they reduce absorption of sugars and fats and starve cancer cells????)
STATINS – Simvastatin. Several epidemiological studies and in vitro testing has demonstrated that statins have an anti-cancer effect, especially on ovarian cancer. … The mutation rate of TP53 in ovarian cancer is as high as 95% while HMGCR is often highly expressed in TP53 mutant tumours. It seem unrealistic for a lipid-lowering drug to completely inhibit tumour growth. Therefore, statins play more synergistic roles in the treatment of ovarian cancer. pmc.ncbi.nim.nih.gov STATIN - Pitavastatin can inhibit the growth of ovarian cancer xenografts but only if the diet Is modified to eliminate geranylgeraniol.
STATIN - BESTATIN – more research has found this is effective against ovarian cancer cells
STATIN - PITAVASTATIN + IVERMECTIN
Ivermectin augments the anti-cancer activity of Pitavastatin in Ovarian Cancer CellsBy Mohammed Jasmin Jaward and Alan Richardson. The School of Pharmacy and Bioengineering, Keele Uni. // College of Veterinary Medicine, Kerbala Uni.“We have previously shown that pitavastatin has the potential to be used to treat ovarian cancer, although relatively high doses are likely to be necessary. One solution is to identify drugs that are synergistic with pitavastatin. Here, tested with anti-parasitic drug ivermectin in six ovarian cancer cell lines. When tested on its own, ivermectin inhibited the growth of the cells but only with modest potency. When combined, ivermectin showed synergy with pitavastatin in 3 cell lines, most evident in COV-318 cells. We and many others have explored the potential for statins to be repurposed for use as anti-cancer agents. Numerous laboratory studies have shown statins exert cytotoxic effects against cancer cells. We have shown that one statin, pitavastatin can inhibit the growth of ovarian cancer xenografts, but only if the diet is modified to eliminate geranylgeraniol which otherwise bypasses the block ade of hydroxymethyl glutaryl coenzyme. Despite robust preclinical data showing that statins have anti-cancer activity, statins have yet to show significant activity in clinical trials. “We have argued that this reflect the poor design of clinical trials which have uniformly failed to address all the factors we predict influence the clinical activity of statins. This failure includes poor choice of statin, inappropriate dose, inappropriate dosing interval, and failure to consider dietary sources of geranylgeraniol. Lipophilic statins are typically more potent as anti-cancer agents than hydrophilic ones. We consider pitavastatin most likely statin to be effective as an anti-cancer agent. However, relatively high doses are likely to be required. The major adverse event is myopathy, although infrequent.ANTI-CANCER HERBS, SPICES ETC. Ginger, Parsley, and Cloves
PRP anti-angiogenic. Combination of Trypsinogen and Chymotrypsinogen. Bovine pancreatic pro-enzymes. Significantly inhibited advanced pancreatic and ovarian cancers. Patients lived significantly longer than expected. Treated daily with rectal suppositories. https://pmc.ncbi.nim.nih.gov.articles/pMC5656647/1 (Maybe available to purchase as oral anti-inflammatory medication. Trypsin & Chymotrypsinogen. May not be absorbed so well.)
BOOKSTHE CANCER RESOLUTION, by Mark Lintern (available on Amazon). A new cancer theory. You can listen to interviews with him on You Tube. Well worth a ‘listen’. I have purchased his book – which is ‘big’ read. (Cancer is not a genetic disease).
HOW TO STARVE CANCER by Jane McClelland. (Highly recommended. THE MOST helpful read.)
EXPLANATION OF LONG – MEDICAL WORDS
APOPTOSIS A type of cell death in which a series of molecular steps in a cell lead to its death. The process may be blocked in cancer cells.
AUTOPHAGY is the natural conserved degradation of the cell that removes unnecessary or dysfunctional components through lysosome-dependent regulated mechanism.
CYTOTOXIC EFFECTS how harmful a substance is to an organism – to cells. Can cause cell damage or death, either through necrosis or apoptosis.
Glycolysis – METABOLIC PATHWAY THAT CONVERS GLUCOSE INTO PYRUVATE AND, IN MOST ORGANISMS, OCCURS IN THE LIQUID PART OF CELLS. The free energy released I this process is used to form the high energy molecules adenosine triphosphate and reduced nicotinamide adenine dinucleotide.
Metastatic Cancer – Cancer that has spread from where it started. For many types of cancer, it is also called stage 4 cancer.
Necrosis is the death of body tissue. It occurs when too little blood flows to the tissue. This can be from injury, radiation or chemicals. Necrosis cannot be reversed. Can occur due to injuries, infections or diseases.
Xenograft: Patient derived xenografts are models of cancer where the tissue or cells from a patient’s tumour are implanted into an immunodeficient or humanized mouse.
(Good luck and please do share your research)
susan.k.moore@btinternet.com